Endocrine Abstracts

Polycystic Ovary Syndrome (PCOS), the most common endocrinopathy of reproductive-age women, was initially defined by the association of anovulation and clinical and/or biochemical hyperandrogenism (1990 NIH). Since Rotterdam Consensus Conference in 2003, its diagnosis requires the presence of at least two of the following features: oligo-/anovulation, hyperandrogenism and polycystic ovaries on ultrasound. However, since its introduction, this definition was strongly challenged...

Diet, and especially metabolic dysregulation such as obesity can influence the ovarian activity. Adipose tissue plays an important role since it is known to be one of the most important endocrine organs producing hundreds of cytokines, such as adiponectin. Our team has observed that adiponectin modulated steroid secretion by the ovarian granulosa cells and its concentration in the follicular fluid was influenced by the metabolic status. Recently, a small adiponectin mimetic sy...

Context: Klinefelter Syndrome (KS) patients, defined by a 47 XXY karyotype, were long considered infertile. Testicular sperm extraction (TESE) now allows some of these patients to access fatherhood. The predictive factors for success, however, remain unknown.Patients and methods: Non-mosaic KS patients with azoospermia or severe cryptozoospermia on two semen analyses without any other spermatogenesis disorder were included. They were sorted into two age ...

Background: Klinefelter Syndrome (KS) patients, defined by a 47 XXY karyotype, suffer from osteoporosis, with an increased risk of mortality after femoral neck fracture. The mechanisms underlying this bone alteration remain unclear.Patients and methods: In KS patients naïve from testosterone substitution therapy (TST), we assessed bone microarchitecture at distal radius and tibia by High Resolution peripheral Computed Quantitative Tomography, and bo...

Introduction: The human fetal adrenals (HFA) produce high levels of steroids. The gland is distinguishable from the 7th gestational week and can be separated in two zones: the fetal zone in the center which correspond of 80 % of the gland and the definitive zone in the periphery. At this time of the development, neural crest cells are reaching the adrenal primordium, producing catecholamines. A third zone, the transitional zone appears later in the early 2nd</s...